For many women, the phrase "hormone replacement therapy" immediately brings concerns about breast cancer, heart disease, blood clots, and stroke. Much of that fear can be traced back to a landmark study published in 2002 known as the Women's Health Initiative (WHI). The release of the WHI findings dramatically changed the way hormone therapy was viewed. Millions of women stopped treatment, physicians became hesitant to prescribe it, and many women who could have benefited from hormone therapy were left to suffer through menopause symptoms without treatment. More than two decades later, the conversation surrounding hormone therapy is very different than it was in 2002.